Clinical Study Of Neopterin With Cardiovascular Diseases In Iraq Patients

Abstract

Objectives: The aim of our study was to determine neopterin concentration in patients with Cardiovascular Diseases and their relationship with clinical parameters.                                                                                                                                                                                                          

Background: The release of various cytokines activates cellular defense in cardiovascular diseases. As well as in the vascular endothelium and cardiomyopathy, neutrophils and monocytes/macrophages have been found to be infiltrating the artery and the heart, An indicator for those activated macrophages is neopterin, a byproduct of the guanosine triphosphate-biopterin pathway.

75 Methods: blood samples of people with cardiovascular diseases, aged between (35-65) years, of both sexes, from the cardiac care unit at Ibn Sina Teaching Hospital / Mosul / Iraq, and compared with 75 blood samples of apparently healthy people. Neopterin levels were determined with a commercially available enzyme-linked immunosorbent assay  method.                                                                                                                                                                      

Conclusions: Our data support the hypothesis of activation of monocytes and macrophages in patients with cardiovascular diseases. neopterin as a marker for macrophage activation is significantly increased in patients with  CAD .there was a correlation between neopterin and clinical parameters as markers for the extent of the Atherosclerosis