SYNTHESIS AND SCREENING OF NOVEL MANNICH AND SCHIFF BASE DERIVATIVES OF ISATINS FOR CYTOTOXIC AND ANTIOXIDANT ACTIVITY

Abstract

A series of novel of 1-{[bis(2-chloroethyl)amino]methyl}-3-(phenylimino)1,3-dihydro-2H-indole-2-one derivatives(IIIa-j) were synthesized using appropriate methods. Structural confirmation for the synthesized compounds were done by spectral studies such as 1HNMR, MASS,IR etc. All the compounds were tested for cytotoxicity assay and antioxidant activity. All the compounds showed good cytotoxic activity. Of them, compound IIIi (R=4-F) was observed to possess more cytotoxic activity. All the derivatives were screened for antioxidant activity and the results were compared with the standard drug Ascorbic acid.  All the series of the compounds showed antioxidant activity. Compound IIIi (R=4-F) was found to be more effective antioxidant.