PREPARATION AND EVALUATION OF INTRANASAL NANOEMULSION OF SUMATRIPTAN

Abstract

Purpose: This study aimed to prepare and evaluate intranasal nanoemulsion of sumatriptan.

Methods: The mucoadherent Nanoemulsions were developed by first creating a drug nanomulsion with the least amount of external phase and then adding the needed amount of concentrated polymer solution to it to get the desired final concentration. Suamtriptan Mucoadhesive nanoemulsion was made as stated in sumatriptan nanoemulsion preparation, and chitosan was added for 30 minutes while continuously stirring. Droplet size and size distribution analysis, as well as polydispersity index (PDI), were performed on the prepared mucuadhesive nano emulsion.

Results and Conclusion: The F7 batch had the highest% drug concentration of 96.12 0.052% when the% drug content was calculated. The optimal concentration of oil, surfactant, and co-surfactant was required for maximal drug loading in the formulation in order to achieve maximum drug content in the optimised batch (F7). The cumulative% drug release profile of STS from trial batches of formulation was determined to be 83.433.25% for F7 batch using dialysis membrane at PBS (pH 6.4). Batch F7 had the highest percentage of cumulative drug release from a mucoadhesive nanoemulsion.