Phytochemical Analysis, Antibiofilm And Antibacterial Activity Of Crude Methanol Extract Of Careya Arborea Fruit Against Multi Drug Resistant Strains

Abstract

Aim: The present study reports the phytochemical analysis of fruits extracts of Careya arborea and their evaluation for antibacterial and antibiofilm activity against multi drug resistant isolates.

Methods: The fruits of Careya arborea extracted using six solvents, and fractionated with column chromatography.   The fractions were evaluated for their antibacterial and antibiofilm activities against few of the clinical MDR isolates of human pathogens.

Results: Phytochemical analysis of fruit Careya arborea revealed the presence of alkaloids, tannins, saponins, steroids, terpenoids, flavanoids and cardiac glycosides. Minimum inhibitory concentration was found to be 17.45 mg/µL and 6.9 mg/µL for antibacterial and antibiofilm activities respectively. Comparatively, E.coli, Salmonella and Shigella were resistant to the extracts.

Conclusion: Further analysis and characterization of the bioactive molecules from the fruits of Careya arborea may lead to the discovery of new compounds against the virulence by multidrug strains.