SYNTHESIS OF ALPHA, BETA UNSATURATED CYCLIC KETONES VIA ROBINSON ANNULATION REACTION

Abstract

A Chalcones (3a-l) and (5a-c) were used to create some brand-new cyclohexanone compounds (6a-f) and (7a-c), respectively. Accordingly modified benzaldehyde, 2-hydroxy-1- naphthaldehyde, and cinnamaldehyde were base-condensed with 1-tetralone to produce the chalcones (3a–l), while benzaldehyde and 1-indanone were base-condensed with benzaldehyde to produce the chalcones (5a–c). The cyclohexenone (6a-f) was produced by the reaction of prepared chalcones with ethyl acetoacetate via Robinson annulation (7a-c). Physical and spectral approaches have been used to characterize all produced compounds.