DENTAL IMPLANTS BEFORE DURING AND AFTER BISPHOSPHONATE THERAPY - A SYSTEMATIC REVIEW

Abstract

Aim: To review articles that compared diphosphonate therapy patients who received dental implants before, during, or after bisphosphonate (BP) treatment to healthy patients, looking at the increase in implant failure and loss, as well as the incidence of bisphosphonate-related osteonecrosis of the jaw (BRONJ).

Methodology: After performing the extensive search on electronic databases PUBMED searched articles until Jan 2022 using MeSH terms and the systematic review in done according to prisma guidelines.

Results: There were 375 articles found after the search. After being chosen based on the qualifying criteria, 15 papers were included (eight retrospective, one prospective, and six case series), totaling 1339 patients, 3748 implants implanted, 152 implant losses, and 78 BRONJ instances.

Conclusion: Because there are few randomized clinical trials on this topic, more research with longer follow-up is needed to answer the remaining concerns. Because of the risk of developing BRONJ and implant failure in patients receiving bisphosphonate medication, it is prudent to exercise caution when considering dental implant surgery in these individuals. Furthermore, when such treatments are conducted, the patient's entire systemic state must be taken into account.