Nail Drug Delivery System for Terbinafine

Abstract

The nail has a structure of horns. The nail plate is to blame for drug penetration across it. Because it is hard enough, only a small amount of topical medication can get through it. As a result, the therapeutic concentration that is effective is not reached. Due to a lack of glow, the nail plate may appear abnormal. It involves the nail bed, reduces blood flow, or has chemical or physical characteristics of the nail bed. Consequently, a variety of diseases emerge. Topical therapies are limited by their low rate of penetration through the nail plate, whereas oral therapies are accompanied by systemic side effects and drug interactions. By using a nail drug delivery system, the desired therapeutic concentration of a drug can be achieved, curing these diseases .In addition to their protective and ornamental functions, human nails can be considered an alternative route for drug delivery, particularly in nail diseases like onychomycosis and psoriasis. The most prevalent nail disorder seen in clinical practice is onychomycosis, a fungal nail infection caused by yeast, dermatophytes, and nondermatophytes. Onychomycosis recurrence prevention strategies and new treatments are also discussed.