Vitamin D deficiency is associated with low levels of tyrosine kinase-2 in ischemic heart diseases

Abstract

Introduction: Vit-D, a fat-soluble vitamin, has a biovital role in the various physiological processes in a living system. its action is mediated through vitamin D receptors (VDR). Worldwide, cardiovascular diseases (CVD) including ischemic heart diseases (IHD), constitute the leading cause of mortality and associated with low vitamin D levels. However, the mechanisms by which low Vit-D levels enhance IHD pathogenesis are not fully understood. This study highlighted in vivo evidence that illustrates the strong links between vitamin D deficiency, and Tyrosine Kinase 2 in patients with IHD. Methods: The study was performed between January 2021 to May 2021. 60 subjects were enrolled in this study with IHD (angina =30, MI= 30) with mean age (59 ± 1.5; 38 males, 22 female), and 60 subjects appeared to be normal healthy persons as the control group with mean age (52 ± 1.2; 51 males, 9 female). Serum Vit-D, VDR, and Tyrosine kinase-2 activity (TK2) were measured by ELISA. Results: The results clearly showed low Vit-D and VDR levels in patient groups with IHD compared to control (P<0.01); a great effect was shown in the MI group. The finding also declared that serum activity of TK2 was significantly decreased in patients with IHD compared to control groups (p <0.01). Conclusions: these findings may go some way towards explaining that numerous mechanistic links between vitamin D deficiency, and TK2 are involved in the pathogenesis of CVD.