Synthesis, Characterization, Anti-Inflammatory And Analgesic Activities Of Some Novel Chalcone Derivatives Derived From 3-((4-Formyl-2-Methoxy Phenoxy) Methyl) Benzonitrile Derivative

Abstract

A series of novel aryl and aroyl-substituted chalcone derivatives were prepared by condensation of vanillin derivative with different acetophenones. Vanillin derivative (3-((4-formyl-2-methoxyphenoxy) methyl) benzonitrile) was prepared by reacting 3-(bromomethyl) benzonitrile with vanillin. All synthesized compounds (4a-4h) were evaluated in vivo for their anti-inflammatory and analgesic activity. Among all the tested compounds 4b, 4c, 4e, 4f and 4g have shown remarkable anti-inflammatory activity when compared to other compounds. Compound 4h has shown moderate anti-inflammatory activity and 4a&4d have shown less anti- inflammatory activity. Among the tested compounds 4a,4b, 4g and 4h were found to have significant analgesic activity and compound 4c,4d,4e,and 4f had moderate analgesic activity. The newly synthesized chalcone derivatives 4a-4h were characterized by IR, Mass and ¹H NMR spectral data.