Insignificant effect of ethanol extract of Dipterocarpus turbinatus (Dipterocarpaceae) bark on selected parameter in alloxan-induced diabetic rats

Abstract

Objective: The present investigation was designed to find out the antidiabetic potency of
ethanol extract of the bark of Dipterocarpus turbinatus by alloxan monohydrate‑induced
diabetic rats. Materials and Methods: The bark powder of D. turbinatus was extracted
with different solvents(according to the polarity of the solvent). Preliminary phytochemical
evaluation of the plants showed different chemical entities including alkaloids, steroids,
flavonoids, terpenoids, and tannins. Ethanol extracts (200 mg/kg and 400 mg/kg body
weight) were used for antidiabetic study. Oral administration of ethanol extract of the
stem bark of D. turbinatus in alloxan monohydrate (150 mg/kg) induces diabetic rats
for 14 days. Results and Discussion: Various parameters such as blood glucose level,
body weight, and various biochemical parameters (plasma cholesterol, serum creatinine,
and urea) were measured by the spectrophotometric method. There was no significant
reduction seen in the blood glucose as compared with the diabetic control from the
200 mg/kg dose (P < 0005), and no positive effect could be shown on biochemical
parameters as compared with the diabetic control group in both concentrations(200 mg/
kg and 400 mg/kg). Conclusion: On the basis of this investigation, we may partially
conclude that D. turbinatus is not a potent antidiabetic agent.