Lack of anthelmintic activity of Kalanchoe pinnata fresh leaves

Abstract

Objective: The main objective was to explore the anthelmintic capacity of Kalanchoe
pinnata (K. pinnata). Materials and Methods: Petroleum ether and methanolic extracts
of K. pinnata were extracted by maceration methods. Both the extracts were investigated
for their anthelmintic activity against Pheretima posthuma. Different concentrations of
25 mg/mL, 50 mg/mL, 100 mg/mL, and 200 mg/mL of both extracts were studied
by determining time of paralysis (PT) and time of death (DT) of the earthworms.
Results: Both the extracts have exhibited no anthelmintic activity even at the highest
concentration of 200 mg/mL. A concentration of 15 mg/mL of albendazole was used as
standard reference or positive control while normal saline was used as negative control.
Conclusion: This study has revealed that in vitro anthelmintic activity of K. pinnata
leaves lacks anthelmintic property. Both the extracts of this plant have displayed no
vermicide activity against the earthworms used in the study