Comparison of Various Fillers on the Physical Properties of Compounded Tablets

Abstract

Compounded tablets are solid dosage forms that contain active pharmaceutical ingredients that are usually formulated with suitable pharmaceutical excipients. Fillers are inert ingredients used as bulking agents that can affect the physical properties of the final compounded tablet. The objective of this study was designed to compare various types of fillers on the physical properties of compounded tablets. The fillers used in this study were starch, lactose monohydrate, microcrystalline cellulose, GranuLac 200, SorboLac 400, and CombiLac. The wet-granulation method was used to compound the tablets, and the physical characterization of the compounded tablets was evaluated for their weight variation, hardness, thickness, friability, and disintegration. Formulation 2a, which incorporated 50 mg of A. muricata extract and 200 mg of starch as a filler, was chosen as the most optimum formulation as it produced the best physical characterization test results when compared to other formulations. Formulation 2a disintegrated within the specified time limit of 7.41 minutes while having the desired hardness and friability of 5.52 kg and 0.67%, respectively. Moreover, it produced a uniform weight and thickness. Formulations 1, 2, and 7 possessed promising properties, suggesting its potential for compounding tablets containing A. muricata extract as a tablet supplement. These findings warrant further thorough investigations.