Exploration Into Crystalline Forms Of Prulifloxacin

Abstract

Some new crystalline forms of prulifloxacin, a fluoroquinolone antibiotic, were successfully prepared through solvent evaporation and solvent change (combined antisolvent addition/cooling) methods of crystallization using selected solvents of different polarities. The physicochemical differences among procured crystalline form and prepared new crystalline forms were established by characterization through melting point determination, polarizing microscopy, Fourier transform infra-red spectroscopy (FT-IR), powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) and thermo gravimetric analysis (TGA) techniques. Among prepared crystalline forms at least five forms have been ascertained to be definitely newer polymorphs of prulifloxacin as proven by significant characteristic differences.