Development of Nanocrystal Formulations With Improved Dissolution And Bioavailability for BCS Classs-II Drug- Quitapine

Abstract

The aim of the present work was to improve the solubility and bioavailability of  BCS Class-II Drug Quetiapine  using nanocrystal approach.Quitapine nano crystals were prepared by  bottom up technology.The resultant nanocrystals were characterised for its physio chemical parameters such as Melting point,solublity,Particle size and drug release  From the results it is  investigated that prepared nano crystals had improved  solubility and particle size compared to pure drug.Among the prepared formulations F6 had shown 97% Drug release in thirty minutes which  was 15 times more faster than the pure drug with reduce particle size for optimised formulation of 400nm (F6) using PVP k30 as a stabiliser. Drug Excipient compatibility studies were carried out using FTIR spectroscopic studies and reveals that there is no interaction between the drug and the selected excipients. From DSC studies it reveals that the reduced melting point of prepared nanocrystal of 126^Oc from 180 ^Oc of the pure drug  clearly distinct the nanosized formation decrease the melting point increase the solubility and dissolution values this may be attributed to the weaker bonds of drug with the stabiliser.Thus  nano crystal approach is an effective technology in improving the bioavailability of the pure drug quetiapine.