A Review: “Hydrotropy” Techniques to increase the solubility of Drug

Abstract

Solubility is a crucial parameter which is desired for any dosage form to centralize the medicament and the pharmacological action to occur. The prominent challenge faced during the drug discovery is the poor aqueous solubility of the drugs which eventually lead to low dissolvability and low bioavailability of the medicament. In order to increase the solubility, various methods have been adapted. The review grabs the attention towards the concept of hydrotropy, one of the solubilization techniques, in which, adding a second solute to the primary one. It is superior with high efficiency, low side effects, high selectivity, and eco-friendly, easily available and cost effective. It is one of the techniques that enhance the systemic bioavailability and solubility to many folds with the use of hydrotropes like urea, nicotinamide, sodium benzoate, sodium citrate, propylene glycol, glycerol, PEG (200-600), PEG (2000-6000). The technique is favorable for the formulation of parenteral dosage form for poorly water soluble drug, causing the problem of gastric irritation and dysphagia. Other than parenteral it is useful for topical and oral also. Moreover, this review comes up with future insights for drug delivery and hydrotropism.