Synthesis, Characterize and Antibacterial Evaluate of Some Novel Compounds Containing 1,3,4-thiadiazole

Abstract

Preparation of 1,3,4-thiadiazol derivatives from the benzoic acid reaction with the thiosimicarbazide in the presence of (POCl3) and (KOH) to give compound [I]. The purified product was reacted with o-hydroxy naphthaldehyde to form the azo compounds [II], After that we reacted the compound [II] with different aromatic Amines to give Schiff base compounds [III]a-i. All these compounds have been characterized based on F.T-IR, and some of them based on 1H-NMR, 13C-NMR, MP techniques, and The Biological effectiveness of part of them has been studied.