Determination of Triprolidine Hydrochloride Using High Sensitivity Selective Nano-Electrode and Conventional Coated Wire Electrodes

Abstract

The tremendous developments in nanoscience and nanoparticles witnessed great success for nanoparticles due to their unique properties, diverse fields, and uses in a significant way and because they are electrically active, prompting scientific researchers in the various and multifunctional activities of the nanoparticle to give critical attention to these nanoparticles as materials of great usefulness and effective in electrochemical uses as well as for sensing.. This study was able to calculate the potential difference after two electrodes were made to estimate the antihistamine drug triprolidine hydrochloride (TPN) One is the conventional coated wire electrode (I) (TPN-STPB-DEP) and the other is the wire electrode enriched with copper oxide nanoparticles (II()TPN- STPB -DEP-CuONPs) (modified electrode) The results showed that the linear range of the conventional selective electrode (I) is the range of (10-2 - 10-6)mol/L, while the linear range of the nanoscale electrode (II) is the range of (10-2 - 10-8)mol/L, We note that the slope of the electrode of the conventional coated wire and the electrode of the copper oxide (I, II) nanocoated wire are (56.4, 58.321) mV\decade, respectively. It is shown that the estimation coefficients for the manufactured electrodes are (II, I) (0.9990, 0.9986) in a successive manner. Through these results, it was found that the electrode enriched with (modified) copper oxide nanoparticles (II) is more sensitive and selective and has an advantage over the traditional selective electrode (I), And that its advantage in electrical improvement enabled it to quickly perform the search for the drug under study (TPN) with wide ranges of concentrations and low
limits, in addition to the rapid response of the electrode to the drug (TPN).