Prostate Cancer Serum Spectra as Indicators of Early Diagnosis Using FTIR-ATR Fourier Transform Infrared Spectroscopy

Abstract

Prostate cancer is the many typically diagnosed cancer in males. Prostate-specific antigen (PSA) testing allows early diagnosis of prostate cancer despite the poor sensitivity and specificity of the patient's blood, which requires the need for better tools to diagnose this disease. This study investigates the possibility of using Fourier transform infrared spectroscopy. (FTIR-ATR) for spectroscopic comparison between healthy and infected serum, where the highest absorbance was for prostate cancer patients in addition to the loss of some functional groups for the spectrum of patients and a shift in the spectrum of patients from the spectrum of healthy patients, which can be used in the accurate and early diagnosis of this type from cancer. This research revealed that P-values for each ratio I4, I6, and I7 were less than 0.05 (P 0.05). It was statistically significant, although the ratios I1, I2, I3, I5, I8, and I9 were not; hence, the ratio values of each I4, I6, I7 can be used in the early detection of prostate cancer and to distinguish between normal and malignant tissue in the prostate gland in men.