A Comparative Study Between Different Doses Of Intravenous Dexmedetomidine In Attenuation Of Pressor Response To Laryngoscopy And Endotracheal Intubation

Abstract

Objectives: We compared the attenuation of pressor responses by 2 different doses of intravenous dexmeditomidine to laryngoscopy and endotracheal intubation.

Methods:
A randomized, prospective, comparative, double-blinded study was conducted in 80 adult patients who were randomized into two groups of 40 each, Group A and Group B. Group A patients were given 0.5µg/kg Dexmedetomidine in 10ml of normal saline over 10 min prior to intubation. Group B patients were given 1µg/kg Dexmedetomidine in 10ml of normal saline over 10 minutes prior to intubation. Baseline vital and hemodynamic parameters were monitored during the perioperative period after drug administration, at intubation,1,2,3,5,10,15,30 minutes post intubation.

Results: The attenuation of HR after intubation was much better with a dose of 1mcg/kg than 0.5mcg/kg. As there is statistically significant difference in the mean HR between the two groups at  intubation, post drug administration, 1,2,3,5,10,15,30 minutes after intubation with the HR significantly lesser in the Group B than the Group A at all times after intubation. Both doses of dexmeditomidine were effective in attenuating HR response after intubation, but 1mcg/kg dose was more effective than 0.5mcg/kg dose as HR, SBP, DBP and MAP in the Group B remained much lower than the Group A and the difference between the two groups was statistically significant at all times after intubation.

Conclusion:
We concluded that the dose of dexmedetomidine at 1mcg/kg was better than a dose 0.5 mcg/kg dexmedetomidine in preserving hemodynamics while performing direct laryngoscopy and endotracheal intubation.