Solubility Enhancement Of Mangiferin By Solid Dispersion

Abstract

The main intension of the present study is to enhance solubility and oral bioavailability of mangiferin naturally occurring bioactive compound having poor solubility by the different methods like kneading method and solvent evaporation method. The solid dispersions were made by using variety polymers like cross povidone, sodium starch glucolate, lecithin, β-cyclodextrin in ratios of 1:1,1:2,1:3,1:4 and 1:5. Phase solubility studies, Differential scanning calorimetry, X-Ray powder diffraction and fourier transform infrared spectroscopy were used to evaluate compatibility of mangiferin with selected polymers. Solid dispersions prepared by kneading method with sodium starch glycolate in 1:2 ratio shown maximum solubility of 791micrograms per ml (0.791mg/ml) compared with pure drug 57 µg/ml (0.057mg/ml). Therefore it is formulated as tablet by direct compression method. Physicochemical properties and invitro dissolution studies are conducted to characterise tablets. The prepared solid dispersion shown maximum 98.3% release in 1h.