Metabolomics: A New Perspective to Persian Medicine

Abstract

Background: In recent years, research on how traditional medicine works and the relationship between medicine and classical medicine has increased. In this regard, the use of metabolomics is one of the main candidates that can reflect the state of the body's basic metabolism and may be able to explain a new way to explain the function of traditional medicine by evaluating its effect based on evidence and modernizing it under the supervision of new sciences.
Materials and methods: In this review study, in an advanced search from papers published in English language from 2003 to 2020 with key words of “traditional medicine”, “temperament” and “metabolomics” in the databases of PubMed, Medline, Science Direct, Cochrane, Embase is used.
Result: Animal and human studies conducted to relate the concepts of Traditional Chinese Medicine and metabolomics. The results of
studies showed the specific metabolic profile in subtypes of diseases based on theory of Chinese Medicine. In field of Persian Medicine
(PM), limited researches have been published on the differentiation of proteomics and metabolites of individuals with different Mizaj.
Conclusion: Metabolomics has a potential role to establish a new approach to understanding the main concepts of PM such as Mizaj,
classifications of diseases and effectiveness of traditional formula on humans with different Mizaj. Given that most of the research work is focused on herbal medicines and diseases and the important issue of temperament in human samples has done less work, it seems that in modernizing traditional medicine using new approaches such as metabolomics, the first step should be the basics of this medicine should be removed.