Improvement Of Aminoglycoside Activity Against Multi Resistant Escherichia Coli And Staphylococcus Aureus By Pisonia Alba

Abstract

The current research work was carried out to explore the antibacterial and modulatory activity of Pisonia alba. The antibacterial activities of leaf (LEPA) and root (REPA) extracts alone or in association with aminoglycosides were determined by a microdilution test. Multiresistant strains of Escherichia coli (Ec 27) and Staphylococcus aureus (Sa 358) were used. The results show the inhibitory activity of LEPA against E. coli (minimal inhibitory concentration [MIC] 16 μg/mL) and S. aureus (MIC 128 μg/mL). The synergistic effect of the extracts and aminoglycosides was verified too. The maximum effects were obtained with REPA with gentamicin against E. coli with MIC reduction (312 to 2 μL). The data from this study are indicative of the activity antibacterial of extracts of P. alba and its potential in modifying the resistance of aminoglycosides.