Anti-Oxidant Studies, GC–MS Analysis Of Phytoconstituents From Evolvulus Nummularius And Molecular Docking Interactions With Target Proteins In NAFLD

Abstract

Evolvulus nummularius Linn is medicinal plant, belonging to the family Convolvulaceae, also known as Round leaf bind weed reported from the tropical countries, with ethno-botanical values and is familiar for its ethno medicinal applications. It comprises of a series of phytochemicals such as oleanolic acid, ursolic acid, saponins, triterpenoids etc. The study was carried out to explore and characterize the bioactive components of methanolic extract of E. nummularius Linn. The leaves were collected, shade dried, pulverized and extracted by soxhlation with methanol as a solvent. The crude extract was analysed for secondary metabolites and characterized using Gas Chromatography – Mass Spectroscopy. Some of the compounds were analysed for their bioactivity through insilico molecular docking studies. The insilico molecular docking was performed to confirm its binding interactions against target proteins. The results have revealed the presence of many nphytoconstituents and identification of target receptors against Non Alcoholic Fatty Liver(NAFLD) and will create a way for several ailments which lead to the development of novel drugs. However, additional studies are required to achieve its exploration of bioactivity and toxicity.