CHARCTERIZATION, PRE-CLINICAL EVALUATION OF NOVEL OXADIAZOLE DERIVATIVES

Abstract

The practice of medicinal chemistry is devoted to the discovery and development of new therapeutic agents for treating different diseases. Novel 7-Azaisatin, Oxazolone, Oxadiazole derivatives possess various pharmacological properties as per literature studies. The aim of this research work is to synthesize novel substituted 7-Azaisatin, Oxazolone, Oxadiazole by synthetic methodologies and to evaluate the biological activity.
The present study focuses to design “New 7-Azaisatin, Oxazolone, Oxadiazole Derivatives”. Total 30 compounds were synthesized by three different schemes. The synthesized compounds were categorized into 7-azaisatin derivatives (VIIA-VIIL) ,Oxazolone derivatives (OXA01-OXA09),Oxadiazole (OXDO01-OXDO07). Reactions were carried out by reflexing at temp of 75℃-80℃ and some at rt. Most of the reactions were completed in shorter times and products were obtained in good yields. The structure of synthesized compounds were established by IR,1H NMR,C NMR spectral studies.
The newly synthesized compounds were evaluated for their against different cancer cell lines by the standard MTT assay method. All the synthesized novel derivatives were found to be potent biological activities.