Evaluation of Local Tranexamic Acid on Septoplastic Surgery Quality

Abstract

Objective: Septoplasty is a surgical procedure that is used to correct abnormalities of the nose that are either genetic or the consequence of traumatic injury. Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine, and its antifibrinolytic properties are attributed to its irreversible binding to the lysine binding sites on plasminogen molecules. The objective of this study was to evaluate the local TXA in septoplastic surgery quality.
Methods and Materials: It was the goal of this prospective, randomized, double-blind study, which was approved by the Research and Ethics Committees of the AJA University of Medical Sciences and the Iranian Registry of Clinical Trials, and which received written informed consent from all participants, to evaluate the effects of local TXA on the septoplastic surgery field. The study was conducted among 60 patients (thirty patients in each group) at the Imam Reza Hospital in Tehran, Iran.
Results: The (demographic characteristics) gender, age, and weight did not vary statistically significantly between the two groups, and neither did their height and weight. The researchers found that there were no statistically significant variations in mean arterial pressure or heart rate fluctuations between the two groups.
Conclusion: TXA has been shown to have hemostatic properties, and there is no doubt about it. According to the researchers, TXA has been demonstrated in multiple clinical studies and meta-analyses to reduce blood loss while not increasing the risk of DVT and PE complications. Other medication delivery strategies, such as intramuscular injection, oral administration, and intra-articular injection, are available in addition to the ones mentioned above. In multiple experiments, it has been shown that the quantity of intravenous TXA solution that reaches the target region is very little. Due to the heightened coagulation status of the whole body, as well as the potentially life-threatening consequences of thrombosis difficulties, local application is the preferred method of administration.