Express Analysis in Acute Poisoning with Some Antihelminth Drugs

Abstract

In the practice of chemical-toxicological analysis, cases of poisoning of people with certain antihelmintic drugs have become more frequent. Some antihelmintics are on the WHO Model List of Essential Medicines, the World Health Organization's list of essential medicines, which lists the most effective, safest and most affordable medicines. Despite worldwide recognition, effectiveness, availability and low cost, they have an important drawback - serious side effects. In cases of poisoning, it is important to conduct an accurate analysis of blood and urine for emergency medical care. Chemical-toxicological analysis of biological fluids requires accurate and accessible methods. At the same time, the correct and clean extraction of a poisonous substance from biological fluids makes it possible to accurately and quickly determine it. Methods for isolating antihelmintic preparations from biological fluids in acute poisoning have been developed. The extracts were purified from ballast substances by elution by TLC. A chromatographic analysis of antihelmintic preparations isolated from biological fluids was carried out.