The Influence Of Various Methods Of Treatment Of Juvenile Dysmenorrhea On The State Of Reproductive Health In Uzbek Women With Genetic Determination Of Connective Tissue Dysplasia

Abstract

A clinical and genetic examination of 118 girls with painful menstruation, with signs of CTD - 64 and without it - 54, was carried out, the control group consisted of 68 healthy girls with normal menstruation with an assessment of the state of reproductive health after 8 years. It was found that the single nucleotide variant COL1A1 G2046T plays a role in the pathogenesis of the development of JD accompanied by CTD, which is indirectly confirmed by the indicators of hydroxyproline, the increase in the level of which was significant both in comparison with practically healthy individuals and in comparison with a group of patients with JD without signs of CTD. Carrying out a differentiated approach to the treatment of JD, taking into account the presence of phenotypic manifestations of connective tissue dysplasia, allows you to correct menstrual function, prevents further disruption of connective tissue metabolism with normalization of the hypothalamic-pituitary-ovarian activity and the implementation of the function of the reproductive system.