Analysis of Vitamin B 12, Folate and Ferritin with Thyroid Hormones in Hypothyroidism

Abstract

Thyroid hormones are required for normal development as well as regulating metabolism in the adult. Thyroid gland disorders
are the second most abundant endocrinal disorders after diabetes. A decreased thyroid hormone adversely affects the
erythropoietic system that causes anemia.
Aim: The Aim and objective of the study was to compare the vitamin B12, Folate and Ferritin with thyroid hormones in
hypothyroidism.
Methods: In the present study, total 250 samples were included in which 125 were hypothyroid patients and 125 were
normal individuals of age group between 25-60 years. Serum concentrations of Total T3, Total T4, TSH,Vitamin B12, Folate and
Ferritin were measured using Chemiluminescence Immunosorbent Assay.
Results: Serum TSH levels were significantly increased in Hypothyroidism as compared to normal individuals (8.45±1.45 vs2.99
±1.12, p<0.001). The total T3 level was significantly decreased in Hypothyroidism in comparison to the normal individual
(0.49±0.41vs1.45±0.59, p<0.0001*).Similarly, the total T4 level was significantly decreased in Hypothyroidism in comparison to
the normal individuals (3.10±1.45 vs. 6.82±1.10, p<0.001).The level of Vitamin B12 was significantly decreased in
Hypothyroidism in comparison to the normal individual (280.45±159.30 vs 683.93±364.74, p<0.001.Ferritin was also observed
significantly decreased in Hypothyroidism in comparison to normal (53.08±1.18 vs83.43±3.30, p<0.001*)
Conclusion: The Lower values of above these parameters in hypothyroidism interpret that thyroid hormones are
metabolic hormones and produce an impact on our metabolic and hormonal balance and hence, the hemopoietic system is
adversely affected.