Chronic Spontaneous Urticaria And Thyroid Hormones In Iraqi Patients

Abstract

Background: Chronic urticaria has for some time been believed to be related with immune system conditions, specifically autoimmune thyroid disease  (AITD). Chronic spontaneous urticaria (CSU) is viewed as an immune system issue (category I and category II) in half, all things considered.

Current International Guidelines additionally group CU as CSU as well as inducible urticarial, as per nonattendance or existence of ecological setting off component.

Objective: We conducted this controlled study to detect a possible relationship between the thyroid dysfunction and chronic spontaneous urticaria.

Patients And Methods: This case control study was led in Tirit Teaching Hospital from July 2020 to July 2021 to evaluate the relationship among CSU and thyroid dysfunctional. The review bunch included 50 patients with CSU and 40 controls without urticaria and without thyroid sickness.

Serum levels of free T4, TSH, anti-TPO and anti-TGA elevation were assessed in 50 patients and 40 controls utilizing enzyme immunoassay.

Results : There was altogether increment of TSH and TGA in CSU than control, while there is no critical distinction in mean serum of T4 among patients and controls (P> 0.05).

Antibodies to TPO was positive in 9 (18%) patients and to TGA was positive in 12 (24%) patients. Hypothyroidism was altogether greater on patients over controls. (12% versus 0%) (P<0.05), and there is no huge contrast among patients and controls as respect hyperthyroidism (6% versus 0%) .

Conclusions: All in all, CSU is probable an immune system illness. Our  review has shown that thyroid autoimmunity is greater unavoidable in CSU patients differently in everybody.

Patients with CSU has greater risk of thyroid autoimmunity and hypothyroidism.