Calcium To Magnesium Ratio In Senile Cataract Patients: A Case-Control Study In A Tertiary Care Centre

Abstract

Background: Cataracts are one of the main causes of vision loss and age-related cataracts are the most common. The role of the ratio
of calcium and magnesium in serum (Ca: Mg ratio) in the pathogenesis of senile cataracts remains unclear. So, this study was done as
there is a dearth of knowledge about the relationship between senile cataracts and serum calcium: magnesium ratio.
Aim: The aim of the study is to establish the serum calcium: magnesium ratio in senile cataract patients and normal healthy individuals
without cataracts and to correlate the calcium: magnesium ratio with the risk of senile cataracts.
Materials And Methods: This is a case-control study with 50 senile cataract individuals and 50 normal healthy individuals without
cataracts as controls. Serum calcium was determined by the Arsenazo III method and serum magnesium by the Formazan dye method
using Vitros 5600 auto analyzer.
Results: The study shows a significantly decreased concentration of serum magnesium and an increased concentration of calciummagnesium ratio (p<0.001) in ARC (area under the curve) when compared to the control using the ANOVA test.
Conclusion: Increased serum calcium-magnesium ratio were significantly associated with a high risk of cataract formation in patients
with age-related cataract.