The Role Of The Biomarkers Interleukin-18 And Transforming Growth Factor-Beta-1 In Predicting And Detecting Diabetic Nephropathy In Patients With Type 2 Diabetes

Abstract

The current study was conducted on men suffering from type 2 diabetes in Dhi Qar Governorate, Iraq. The study aimed to assess the
levels of some biomarkers in type 2 diabetic patients and their relationship to diabetic nephropathy, including interleukin18 and
transforming growth factor beta1, and included in the study (88) blood samples from men only. They were distributed as follows: 60
serum samples from men with T2DM and 28 serum samples from healthy men. The study samples were collected in cooperation with
Shatra Hospital, as samples were classified into patients according to the disease severity and the duration of . The results of the current
study showed a significant increase in the concentration of IL-18 and TGFb-1 in the samples of patients suffering from T2DM compared
with the healthy ones. This study concluded that there was a significant increase in the concentration of IL-18 in patients in the second
category compared to the first category with respect to the disease severity , as well as a significant increase in the duration of disease in
the first category compared with the second category, and this study concluded the possibility of adopting these indicators as early risk
predictors of diabetic nephropathy.