Interleukin 22 (IL-22) As Biomarker For Rheumatoid Arthritis In Iraqi Population

Abstract

Objectives: To evaluate the significant importance of IL-22 as Biomarker for diagnosis of Rheumatoid Arthritis. RA is the common
inflammatory polyarthritis found in medical care. RA is an autoimmune disorder of gradual onset and unclear cause affecting 1% of
human, women more than men.
Material and Methods: A serum sample was collected from two groups. The first group was patients with Rheumatoid Arthritis (RA),
the Second group was healthy volunteers. serum of this sample used to detect IL22 level was quantified by using ELISA.
Result: The serum IL-22 level was higher in patients with rheumatoid arthritis in compare with control group, 129.30 (33.70) versus
8.18 (3.02), respectively (p< 0.001). Interlukin-22 (IL-22) preferential production of interleukin22 (IL22) by T cells shows that higher
cytokine level occurring chronic, T cell-mediated conditions such as RA.
Conclusion: IL22 level in this study which was bushed to using them as a biomarker for RA diagnosis.