Serum Claudin-5 Level As A Predictor Of Changes In The Microvascular Endothelium In Young Women With Polycystic Ovary Syndrome

Abstract

Background: Polycystic ovary syndrome (PCOS) is a complex syndrome involving both endocrine and metabolic disorders.
Additionally, the most common reason for infertility in women of reproductive age, with a variety of clinical symptoms. Claudin-5
(CLDN5) is the most enriched tight junction protein and is critical to controlling endothelial cell polarity and pericellular
permeability.
Aim of the study: In the current study, the serum CLDN5 level and its affecting factor were examined in patients with recently
diagnosed polycystic ovarian symptoms (PCOS).
Materials and methods: An age-matched case-control study included 90 recently diagnosed PCOS women as patients group using the
Rotterdam criteria and 90 normally infertile women as the healthy control group. ELISA was determined CLDN-5, fasting insulin
(FINS) and other hormone levels. The homeostasis model assessment of insulin resistance (HOMA-IR) assessed insulin resistance.
The outcomes were examined using suitable statistical analysis.
Results: According to the study's findings, PCOS women had significantly higher of BMI, LH, LH/FSH ratio, TT, FAI, FSG, FINS,
HOMA-IR, TC, TG, and LDL-C levels than healthy fertile women, PCOS patients' have a significant lower of SHBG and HDL-C
levels. Serum level of CLDN5 was a highly significant increase in PCOS women compared with healthy women (17.18±3.30
vs10.01±4.21), respectively. Furthermore, the result showed a significant positive correlation between CLND5 level with age, LH,
FINS, and HOMA-IR in the PCOS patients group.
Conclusion: Serum CLND5 levels were increased in PCOS patients than in healthy control women and strongly correlated with
elevated HOM-IR levels, Serum CLDN5 may serve as helpful indications for the management of alterations in the microvascular
endothelium in PCOS patients.